Low-cost genome sequencing approach is powering genetics research on mental illness and many other studies

For researchers on the hunt for the genetic roots of disease, the cost of deep whole-genome sequencing makes it challenging ...
Genomics England

Lead Genomic Data Scientist - Cancer (we have office locations in Cambridge, Leeds & London)

Job Description We are looking to hire a Lead Genomic Data Scientist to join our Bioinformatics Consulting team at Genomics ...
GitHub

mergem is a python package and command-line tool for merging, comparing, and translating genome-scale metabolic models.

> mergem --help Usage: mergem [INPUT_FILENAMES] [OPTIONS] mergem takes genome-scale metabolic models as input, merges them into a single model and saves merged model as .xml. Users can optionally ...
ahajournals.org

Aortic Cellular Diversity and Quantitative Genome-Wide Association Study Trait Prioritization Through Single-Nuclear RNA Sequencing of the Aneurysmal Human Aorta

Mural cells in ascending aortic aneurysms undergo phenotypic changes that promote extracellular matrix destruction and structural weakening. To explore this biology, we analyzed the transcriptional ...
The New England Journal of Medicine

Chemical Complexity of Food and Implications for Therapeutics

These epidemiologic patterns highlight the limitations of focusing on genetics alone. Although the Human Genome Project greatly expanded our understanding of hereditary contributions to disease, genes ...
The Lancet

Genome-wide enhancer-associated tandem repeats are expanded in cardiomyopathy

pDivision of Cardiology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada qDivision of Cardiology, Department of Pediatrics, McMaster Children's Hospital, Hamilton, Ontario, Canada ...
PNAS

Haplotype-resolved genome assembly and implementation of VitExpress, an open interactive transcriptomic platform for grapevine

In contrast to most crops, Vitis vinifera benefited little from classical breeding due to their heterozygosis. Strikingly, the main cultivated grape varieties that we see today have remained the same ...
ahajournals.org

Genome-Wide CRISPR Screen Identifies an NF2-Adherens Junction Mechanistic Dependency for Cardiac Lineage

Cardiomyocyte differentiation involves a stepwise clearance of repressors and fate-restricting regulators through the modulation of BMP (bone morphogenic protein)/Wnt-signaling pathways. However, the ...
eLife

Bactabolize is a tool for high-throughput generation of bacterial strain-specific metabolic models

Bactabolize is written in Python 3 and utilises the metabolic modelling library COBRApy (Ebrahim et al., 2013). Bactabolize has four main commands: Draft model generation (draft_model command), which ...