Frontiers

Development and validation of a machine learning-driven mitochondrial gene signature for the diagnosis of breast cancer

Background: Breast cancer (BC) ranks among the most prevalent malignant tumors in women globally, with mitochondrial dysfunction constituting one of its pathogenic mechanisms. Objectives: To ...
C&EN

Structures of Falcipain-2 and Falcipain-3 Bound to Small Molecule Inhibitors: Implications for Substrate Specificity

Department of Cellular and Molecular Pharmacology and Department of Pathology, University of California, San Francisco, California 94158, and the Department of Medicine, San Francisco General Hospital ...
SciELO

Molecular Docking and Dynamic Diterpenoid-Stevia Compounds from Water Maceration-Sonification Extract as Amylase and Glucosidase Enzyme Inhibits

Stevia (Stevia rebaudiana), with its intense sweetness, therapeutic properties, and safety profile, serves not only as a sugar substitute but also promotes holistic metabolic health. This study aimed ...
eLife

Coenzyme-protein interactions since early life

This study presents a valuable examination of the prevalence of interactions between amino acids from different periods of Earth's history and coenzymes. While the premise of this work is well founded ...
PNAS

The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase

Edited by Carl F. Nathan, Weill Medical College of Cornell University, New York, NY, and approved October 5, 2020 (received for review June 30, 2020) ...