AI helps scientists improve prediction of which DNA sequences bind to each other

Researchers have demonstrated a novel AI model that can predict which DNA molecules bind with other DNA molecules. A more ...
ascopubs.org

From Sequencing to Treatment: Operational Challenges in Translating Precision Oncology Into Clinical Practice

In-house testing may shorten clinician-perceived TAT by reducing specimen transfer time from pathology to the sequencing laboratory. 57 However, in-house platforms operating at lower testing volumes ...
eLife

Barcode-free multiplex plasmid sequencing using Bayesian analysis and nanopore sequencing

This study provides an important computational tool for analyzing and deconvoluting a pool of plasmids sequenced without barcoding using nanopore long-read sequencing. The tool, which has been ...
Scientific Research Publishing

Pedagogical Alignment of Large Language Models (LLM) for Personalized Learning: A Survey, Trends and Challenges ()

This survey paper investigates how personalized learning offered by Large Language Models (LLMs) could transform educational experiences. We explore Knowledge Editing Techniques (KME), which guarantee ...
IEEE

A CPU-FPGA Based Heterogeneous Accelerator for DNA Sequence Alignment

Abstract: The BWA-MEM alignment software, known for its efficient algorithm with lower space-time complexity, is extensively used for sequence alignment in low-cost, high-throughput second-generation ...
acm.org

Theoretical Analysis of Edit Distance Algorithms

Edit distance—a classical problem in computer science—has received ongoing attention from both practitioners and theoreticians. Given two strings A and B, the edit distance is the minimum number of ...
GitHub

parasail: Pairwise Sequence Alignment Library

parasail is a SIMD C (C99) library containing implementations of the Smith-Waterman (local), Needleman-Wunsch (global), and various semi-global pairwise sequence alignment algorithms. Here, ...
Frontiers

Exploring microbial functional biodiversity at the protein family level—From metagenomic sequence reads to annotated protein clusters

Metagenomics has enabled accessing the genetic repertoire of natural microbial communities. Metagenome shotgun sequencing has become the method of choice for studying and classifying microorganisms ...
Frontiers

Methods to improve the accuracy of next-generation sequencing

Next-generation sequencing (NGS) is present in all fields of life science, which has greatly promoted the development of basic research while being gradually applied in clinical diagnosis. However, ...