Tvardi Therapeutics’ TTI-109 Phase 1 Study Confirms Prodrug Design, Improved Tolerability and Pharmacodynamic Evidence of STAT3 Target Engagement

TTI-109 delivered TTI-101-equivalent exposure with improved tolerability and meaningful reductions in disease-relevant STAT3-driven immune cell ...
The Lancet

Inherited retinal degenerations: clinical phenotypes and emerging therapies

Inherited retinal degenerations are a diverse group of genetic disorders that result in progressive vision loss. Advances in ...
BMJ Open

Implementation determinants of a planned machine learning-enabled surgical scheduling system in a high-volume orthopaedic centre in Canada: qualitative findin…

Objectives Elective non-emergent surgical wait times have increased across countries such as Canada, straining operating room ...
The Lancet

PERC-Peds rule for bedside exclusion of pulmonary embolism without radiation in children in the USA (BEEPER): a multicentre, prospective, observational, diagnostic a…

In this multicentre, prospective, observational, diagnostic accuracy study of children with suspected pulmonary embolism in ...
ahajournals.org

Ketones and the Heart: Metabolic Principles and Therapeutic Implications

The ketone bodies beta-hydroxybutyrate and acetoacetate are hepatically produced metabolites catabolized in extrahepatic organs. Ketone bodies are a critical cardiac fuel and have diverse roles in the ...
verywellhealth

Protein vs. Carbs for Breakfast: Which Is Better for Blood Sugar?

Elizabeth Barnes, MS, RDN, LDN, is a registered dietitian specializing in eating disorders, type 2 diabetes, and heart health. Pair protein with complex carbs to get both quick and long-lasting fuel ...