ABSTRACT: Background: There is a paucity of data on the efficacy of ventilatory strategies in COVID-19-related ARDS. The aim of this study was to describe the effect of positive end-expiratory ...

ABSTRACT: Importance: The best respiratory support technique to reduce intubation and mortality in patients with respiratory failure due to COVID-19 is controversial. Objective: To determine the ...

Critically ill patients with tuberculosis carry high mortality. Identification of factors associated with mortality in critically ill tuberculosis patients may enable focused treatment. An extensive ...

We present a case of a man in his early 50s, who developed severe respiratory distress following exposure to airbag fumes after a road traffic accident. Despite initial treatment for lower respiratory ...

Lung donation is complex and sometimes the secretion retention makes it impossible. We report a case of a patient that was screened as potential lung donor with PaO2/FiO2 ratio below range. As in ...

The innate immune response plays an important role in the pathophysiology of acute respiratory distress syndrome (ARDS); however, no drug has been proven to be beneficial in the management of ARDS.

Exposure to hyperoxia, a high arterial partial pressure of oxygen (PaO2), may be associated with worse outcomes in patients receiving extracorporeal membrane oxygenator (ECMO) support. We examined ...

1 Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada 2 Department of Medicine, University of Toronto, Toronto, ON, Canada 3 Institute of Health Policy, ...