In one of the first research papers on an antidepressant, “The Treatment of Depressive States with G22355, Imipramine Hydrochloride,” the author noted that “in individuals who are predisposed” the ...

Bipolar episodes can occur at random, but they’re often associated with specific circumstances. By identifying these thoughts, feelings, and events, you can learn to better manage situations that are ...

Bipolar disorder is a long-term mood disorder characterized by major fluctuations in mood — both high and low — that can impact daily functioning and behavior. Although bipolar disorder is a chronic ...

Bipolar disorder exists on a spectrum rather than as a single, uniform condition. This fundamental characteristic explains why two people with the same diagnosis can experience dramatically different ...

The approval of medicines called second-generation antipsychotics has allowed bipolar I and some conditions that come with it to be treated. A person who has bipolar I disorder can go through various ...

Subtle changes before a mood episode are often easiest to spot in hindsight. Here’s what to watch for. Managing a complex, brain-based mood disorder like bipolar requires self-awareness and a measure ...

Schizophrenia and bipolar I disorder are two conditions that have many differences between them. A class of medicines called antipsychotics can be used to treat both conditions but may cause unwanted ...

The essential problem in assessing bipolar disorder with other mental disorders is the lack of a clear roadmap for an accurate differential diagnosis. As I have written before, nearly two-thirds of ...

Bipolar disorder can feel like a storm that erupts from nowhere, yet for decades the brain circuitry driving those brutal mood swings has remained frustratingly vague. Now, converging lines of ...