Expression of the Notch ligand JAG1 and Notch pathway activation promote poor prognosis, basal-like breast cancer. We have recently shown that the pseudokinase Tribbles homolog 3 (TRB3) regulates JAG1 ...
Expression of the Notch ligand Jagged 1 (JAG1) and Notch activation promote poor-prognosis in breast cancer. We used high throughput screens to identify elements responsible for Notch activation in ...
The effect of TRB3 on Akt/PKB was to inhibit its phosphorylation at threonine (Thr) 308 and serine (Ser) 473, thereby reducing its kinase activity — there was no change in the protein levels of ...
Non-alcoholic fatty liver disease has increased in recent years, and is one of the major causes for cryptogenic cirrhosis. Tribble 3 is a mammalian homolog of drosophila tribbles and is also a ...
U.S. researchers have identified a protein that could serve as a new target for drugs designed to treat type II diabetes. The protein, known as TRB3, is actually a homolog of a protein found in the ...
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