Undergraduate biology students could be forgiven for thinking that scientists have DNA replication all figured out. After all, textbooks present the models of replication so matter-of-factly that it's ...

Failures in DNA replication can lead to cancer, birth defects or other harm Video shows single pieces of double-helix DNA being copied Single-molecule view gives new insights into this process ...

Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of DNA ...

Half a century ago, scientists Jim Watson and Alexey Olovnikov independently realized that there was a problem with how our DNA gets copied. A quirk of linear DNA replication dictated that telomeres ...

On their own, however, polymerases aren't good at staying on the DNA strand. They require CTF18-RFC in humans and Ctf18-RFC in yeast to thread a ring-shaped clamp onto the DNA leading strand, and ...

Marie Touchon, Samuel Nicolay, Benjamin Audit, Edward-Benedict Brodie of Brodie, Yves d'Aubenton-Carafa, Alain Arneodo, Claude Thermes, Philip P. Green Proceedings of the National Academy of Sciences ...

DNA replication is required to maintain the integrity of genomic information. This article describes the process of DNA replication, in a step-by-step manner. DNA replication requires unwinding of the ...