There are a lot of practical reasons to set up an OS like Windows 10 in a VM rather than using it as a native installation. If you have to deal with files you can't trust, need to test multiple OS ...

VMware ESXi is an enterprise-class, type-1 hypervisor developed by VMware for deploying and serving virtual computers by integrating vital OS components, such as a kernel; since as a type-1 hypervisor ...

Qubes OS is a free open-source operating system that’s fully security-oriented. It leverages Xen-based virtualization, which allows the user to create, use and delete easily isolated compartments ...