CRISPR-Cas9 is widely used to edit the genome by studying genes of interest and modifying disease-associated genes. However, this process is associated with side effects including unwanted mutations ...

A Penn State-led team of interdisciplinary researchers has developed techniques to improve the efficiency of CRISPR-Cas9, the genome editing technique that earned the Nobel Prize in 2020. While CRISPR ...

Understanding human gene function in living organisms has long been hampered by fundamental differences between species.

For the first time, scientists have found a way to efficiently and precisely remove genes from white blood cells of the immune system and to substitute beneficial replacements, all in far less time ...

PHILADELPHIA— A new approach to the genetic engineering of cells promises significant improvements in speed, efficiency, and reduction in cellular toxicity compared to current methods. The approach ...

A novel genome editing technique, NICER, is based on the creation of multiple nicks in single DNA strands by nickase. The method can correct heterozygous mutations using two mechanisms: multiple nicks ...

The ability to edit the genome by altering the DNA sequence inside a living cell is powerful for research and holds enormous promise for the treatment of diseases. However, existing genome editing ...

Researchers have developed a new "color-coded" genetic method that makes it easy to distinguish male and female mosquitoes. This innovation can help solve a major bottleneck in mosquito control ...