aProximate TM PTCs maintain high expression of key transporters involved in drug handling, including megalin and cubilin, making them ideal for studying drug transporters and drug interactions with ...

Solute carrier (SLC) family transporters are crucial transmembrane proteins responsible for transporting various molecules, including amino acids, electrolytes, fatty acids, and nucleotides. To date, ...

Common Mistakes to Avoid in Order to Improve Translation of Interaction Data to the Clinic Since 2006, when the U.S. FDA published a draft guidance on drug interaction studies, it has expected new ...

Scientists at St. Jude Children’s Research Hospital have drawn on structural biology expertise to determine structures of vesicular monoamine transporter 2 (VMAT2), a key component of neuronal ...

Membrane proteins are the target of most drugs currently on the market due to their relationship with the vast majority of diseases they are designed to treat. Drug activity depends on numerous ...