PEGASUS generates permeable macrocyclic peptides, offering new promise for a modality that can combine the properties of a biologic in a pill ...

It achieves AI-driven generative design of the first permeable macrocyclic peptide with more than two polar or ionizable fragments. -- Surrogate assays are a breakthrough for AI model training. 1910 ...

To understand the focus of startup Insamo Inc., one need look no further than its name, which co-founder and CEO Timothy Craven described as “portmanteau of ‘internally satisfied molecules,’” ...

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An illustration shows how custom-made peptide molecules (shown in pink and purple) can slip through a cell membrane. (Image by Ian C. Haydon / UW Institute for Protein Design) Researchers at the ...

The Tat-SIRT5-CTM peptide specifically blocked the interaction of SIRT5 with ANXA1, led to SIRT5 degradation and thereby inhibiting SIRT5-mediated desuccinylation of ANXA1, which in turn alleviated ...

The Food and Drug Administration (FDA) has accepted for review the resubmitted New Drug Application (NDA) for elamipretide in the treatment of Barth syndrome, a rare mitochondrial disease.

Orbis Medicines emerged from stealth Feb. 29 with $28 million in seed funding. The company is the latest launched to turn cyclic peptide molecules into orally available drugs that could replace ...

Insamo Inc., founded in 2022 to combine machine-learning capabilities, high-throughput screening and genetic engineering to create orally administered membrane-permeable cyclic peptides across a range ...